© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

The first of a series of volumes containing Albright's shorter writings, some never before published, and the rest revised. In this volume Albright develops his philosophy of history more explicitly than elsewhere, elaborating his distinction between proto-logical, empirico-logical and logical levels of thought. He is very critical of philosophical system-building, especially of the idealistic type, and he sharply contrasts post-Kantian developments in epistemology with what he regards to be the correct epistemology of history. In addition to these broad (...) considerations, there are more technical discussions of Near Eastern religions, review articles of philosophical historians, and an autobiographical sketch. This volume reflects the great range and quality of scholarship which have made its author one of America's most famous scholars.—R. J. W. (shrink)

Information can be public among a group. Whether or not information is public matters, for example, for accounts of interdependent rational choice, of communication, and of joint intention. A standard analysis of public information identifies it with (some variant of) common belief. The latter notion is stipulatively defined as an infinite conjunction: for p to be commonly believed is for it to believed by all members of a group, for all members to believe that all members believe it, and so (...) forth. This analysis is often presupposed without much argument in philosophy. Theoretical entrenchment or intuitions about cases might give some traction on the question, but give little insight about why the identification holds, if it does. The strategy of this paper is to characterize a practical-normative role for information being public, and show that the only things that play that role are (variants of) common belief as stipulatively characterized. In more detail: a functional role for “taking a proposition for granted” in non-isolated decision making is characterized. I then present some minimal conditions under which such an attitude is correctly held. The key assumption links this attitude to beliefs about what is public. From minimal a priori principles, we can argue that a proposition being public among a group entails common commitment to believe among that group. Later sections explore partial converses to this result, the factivity of publicity and publicity from the perspective of outsiders to the group, and objections to the aprioricity of the result deriving from a posteriori existential presuppositions. (shrink)

That space and time should be integrated into a single entity, spacetime, is the great insight of Einstein's special theory of relativity, and leads us to regard spacetime as a fundamental context in which to make sense of the world around us. But it is not the only one. Causality is equally important and at least as far as the special theory goes, it cannot be subsumed under a fundamentally geometrical form of explanation. In fact, the agent of propagation of (...) causal influence is electromagnetic radiation. In this examination, the authors find support for a rationalist approach to physics, never neglecting experimentation, but rejecting a simple empiricist or positivist view of science. (shrink)

The author of the acclaimed Gay Fiction Speaks brings us new interviews with twelve prominent gay writers who have emerged in the last decade. Hear Us Out demonstrates how in recent decades the canon of gay fiction has developed, diversified, and expanded its audience into the mainstream. Readers will recognize names like Michael Cunningham, whose Pulitzer Prize-winning novel The Hours inspired the hit movie; and others like Christopher Bram, Bernard Cooper, Stephen McCauley, and Matthew Stadler. These accounts explore the vicissitudes (...) of writing on gay male themes in fiction over the last thirty years--prejudices of the literary marketplace; social and political questions; the impact of AIDS; commonalities between gay male and lesbian fiction... and even some delectable bits of gossip. (shrink)

In this article, Lucas maintains the falseness of Mechanism - the attempt to explain minds as machines - by means of Incompleteness Theorem of Gödel. Gödel’s theorem shows that in any system consistent and adequate for simple arithmetic there are formulae which cannot be proved in the system but that human minds can recognize as true; Lucas points out in his turn that Gödel’s theorem applies to machines because a machine is the concrete instantiation of a formal system: therefore, for (...) every machine consistent and able of doing simple arithmetic, there is a formula that it can’t produce as true but that we can see to be true, and so human minds and machines have to be different. Lucas considers as well in this article some possible objections to his argument: for any Gödelian formula we could, for instance, construct a machine able to produce it or we could put the Gödelian formulae that we had proved as axioms of a further machine. However - as Lucas underlines - for every of such machines we could again formulate another Gödelian formula, the Gödelian formula of these machines, that they are not able to proof but that we can recognize as true. More general arguments, such as the possibility to escape Gödelian argument by suggesting that Gödel’s theorem applies to consistent systems while we could be inconsistent ones, are moreover refuted by Lucas by maintaining that our inconsistency corresponds to occasional malfunctioning of a machine and not to his normal inconsistency; indeed, a inconsistent machine is characterized by producing any statement, on the contrary human being are selective and not disposed to assert anything. (shrink)

This paper addresses the definition and the operational use of intuitions in philosophical methods in the form of a research study encompassing several regions of the globe, involving 282 philosophers from a wide array of academic backgrounds and areas of specialisation. The authors tested whether philosophers agree on the conceptual definition and the operational use of intuitions, and investigated whether specific demographic variables and philosophical specialisation influence how philosophers define and use intuitions. The results obtained point to a number of (...) significant findings, including that philosophers distinguish between intuitions used to formulate (discovery) and to test (justification) philosophical theory. The survey results suggest that strategies implemented to characterise philosophical intuition are not well motivated since, even though philosophers do not agree on a single account of intuition, they fail to capture a preferred usage of intuitions as aspects of discovery. The quantitative summary of survey findings informs the debate on this topic, and advances more defined routes for subsequent approaches to the study of intuitions. (shrink)

From the 5th edition of Beauchamp and Childress' Principles of Biomedical Ethics, the problem of common morality has been given a more prominent role and emphasis. With the publication of the 6th and latest edition, the authors not only attempt to ground their theory in common morality, but there is also an increased tendency to identify the former with the latter. While this stratagem may give the impression of a more robust, and hence stable, foundation for their theoretical construct, we (...) fear that it comes with a cost, namely the need to keep any theory in medical ethics open to, and thereby aware of, the challenges arising from biomedical research and clinical practice, as well as healthcare systems. By too readily identifying the moral life of common morality with rule-following behaviour, Beauchamp and Childress may even be wrong about the nature of common morality as such, thereby founding their, by now, classic theory on quicksand instead of solid rock. (shrink)

A change in sense of self is an outcome commonly associated with Buddhist meditation. However, the sense of self is construed in multiple ways, and which changes in self-related processing are expected, intended, or possible through meditation is not well understood. In a qualitative study of meditation-related challenges, six discrete changes in sense of self were reported by Buddhist meditators: change in narrative self, loss of sense of ownership, loss of sense of agency, change in sense of embodiment, change in (...) self-other or self-world boundaries, and loss of sense of basic self. Changes in sense of self could be transient or enduring, positive or distressing, enhancing or impairing. These changes were also given varied appraisals, ranging from insights associated with Buddhist doctrines to psychopathologies such as depersonalization. In this study of practitioners reporting meditation-related challenges, more global changes in sense of self were associated with higher levels of impairment. These results have implications for both Buddhist meditation as well as mindfulness-based interventions. (shrink)

From all points of the political compass, from widely different groups, have come indignant outcries against the trade in human organs from live vendors. Opponents contend that such practices constitute a morally outrageous and gross exploitation of the poor, inherently coercive and obviously intolerable in any civilized society. This article examines the arguments typically offered in defense of these claims, and finds serious problems with all of them. The prohibition of organ sales is derived not from the principles and argument (...) usually invoked in support of prohibition, but rather, from strong feelings of repugnance which exert an invisible but powerful influence on the debate, distorting the arguments [and working] to the detriment of the [very] people most in need of protection. (shrink)

We extend the theory of “Fine structure and iteration trees” to models having more than one Woodin cardinal.

The application of Gödel’s theorem to the problem of minds and machines is difficult. Paul Benacerraf makes the entirely valid ‘Duhemian’ point that the argument is not, and cannot be, a purely mathematical one, but needs some philosophical premisses to be able to yield any philosophical conclusions. Moreover, the philosophical premisses are of very different kinds. Some are concerned with what is essential to being a machine—these are typically intricate, but definite, easily formalised by the mathematician, but unintelligible to the (...) layman: others attempt to capture what is essential to being a mind, a person or a self—these are typically intuitive, but vague; resistant to exact definition by the logician, but, none the less, widely used and well understood. Gödel’s theorem itself, like many other truths, can be taken either way: it can be taken as a formal proof sequence yielding certain syntactical results about a certain class of formal systems, but it can also be taken as giving us a certain type or style of argument, which we can understand, and, once having got the hang of it, adapt and apply in innumerable different circumstances. In my dispute with the mechanist, I take Gödel’s argument both ways: I first take it as an argument which the mechanist, even according to his own mechanist principles, must accept as scoring some point against his favourite machine; and then I hope that the mechanist, as a man, will see that he can do better and that this sort of argument will always apply against any form of mechanism he espouses. (shrink)

In this paper Lucas comes back to Gödelian argument against Mecanism to clarify some points. First of all, he explains his use of Gödel’s theorem instead of Turing’s theorem, showing how Gödel’ theorem, but not Turing’s theorem, raises questions concerning truth and reasoning that bear on the nature of mind and how Turing’s theorem suggests that there is something that cannot be done by any computers but not that it can be done by human minds. He considers moreover how Gödel’s (...) theorem can be interpreted as a sophisticated form of the Cretan paradox, posed by Epimenides, able to escape the viciously self-referential nature of the Cretan paradox, and how it can be used against Mechanism as a schema of disproof. Finally, Lucas suggests some answers to the most recurrent criticisms against his argument: criticisms about the implicit idealisation in the way he set up the context between mind and machine; questions concerning modality and finitude, issues of transfinite arithmetic; questions concerning the need of formalizing rational inference and some questions about consistency. (shrink)

The legend of the encounter between Wilberforce and Huxley is well established. Almost every scientist knows, and every viewer of the BBC's recent programme on Darwin was shown,* how Samuel Wilberforce, bishop of Oxford, attempted to pour scorn on Darwin's Origin of Species at a meeting of the British Association in Oxford on 30 June 1860, and had the tables turned on him by T. H. Huxley. In this memorable encounter Huxley's simple scientific sincerity humbled the prelatical insolence and clerical (...) obscurantism of Soapy Sam; the pretension of the Church to dictate to scientists the conclusions they were allowed to reach were, for good and all, decisively defeated; the autonomy of science was established in Britain and the Western world; the claim of plain unvarnished truth on men's allegiance was vindicated, however unwelcome its implications for human vanity might be; and the flood tide of Victorian faith in all its fulsomeness was turned to an ebb, which has continued to our present day and will only end when religion and superstition have been finally eliminated from the minds of all enlightened men. Even churchmen concede that it was a disastrous defeat.1 Only Owen Chadwick strikes a note of caution, observing that the account given of the incident in Wilberforce's biography seems hardly consistent with an overwhelming defeat, and maintaining that the received account must be a largely legendary creation of a later date. (shrink)

The issue is obscured by the fact that the word `space' can be used in four different ways. It can be used, first, as a term of pure mathematics, as when mathematicians talk of an `n-dimensional phase-space', an `n-dimensional vector-space', a `three-dimensional projective space' or a `twodimensional Riemannian space'. In this sense the word `space' means the totality of the abstract entities-the `points'-implicitly defined by the axioms. There is no doubt that there exist, iii this sense, non-Euclidean spaces, because all (...) that is claimed by such an assertion is that sets of non-Euclidean axioms constitute possible implicit definitions of abstract entities, that is to say that some sets of non-Euclidean axioms are consistent. If Kant or any other philosopher had denied this, he would have been wrong; but Kant himself took care not to deny it, 2 and there is little reason to suppose that any philosopher concerned about space has been using the word in this, the pure mathematician's, sense. (shrink)

Context: The past few years have presented us with a growing amount of theoretical research (yet that is often based on neuroscientific developments) in the field of enactive music cognition. Problem: Current cognitivist and embodied approaches to music cognition suffer, in our opinion, from a too firm commitment to the explanatory role of mental representations in musical experience. This particular problem can be solved by adopting an enactive approach to music cognition. Method: We present and compare cognitivist, embodied and enactive (...) approaches to music cognition and review the current research in enactive music cognition. Results: We find that, in general, the enactive approaches to human musicality are capable of explaining the basic relationship between a musical subject and a musical object according to a pre-conceptual and pre-linguistic form of understanding related to bodily motor expertise. This explanation does not rely on on sophisticated forms of representation. Implications: Proponents of enactive music cognition should, in our opinion, focus on providing a consistent explanation of the most basic level of musical understanding. Constructivist content: We hope to invite the constructivist community to engage with the discussions on the intersection between music and enactivism. (shrink)

The application of Gödel’s theorem to the problem of minds and machines is difficult. Paul Benacerraf makes the entirely valid ‘Duhemian’ point that the argument is not, and cannot be, a purely mathematical one, but needs some philosophical premisses to be able to yield any philosophical conclusions. Moreover, the philosophical premisses are of very different kinds. Some are concerned with what is essential to being a machine—these are typically intricate, but definite, easily formalised by the mathematician, but unintelligible to the (...) layman: others attempt to capture what is essential to being a mind, a person or a self—these are typically intuitive, but vague; resistant to exact definition by the logician, but, none the less, widely used and well understood. Gödel’s theorem itself, like many other truths, can be taken either way: it can be taken as a formal proof sequence yielding certain syntactical results about a certain class of formal systems, but it can also be taken as giving us a certain type or style of argument, which we can understand, and, once having got the hang of it, adapt and apply in innumerable different circumstances. In my dispute with the mechanist, I take Gödel’s argument both ways: I first take it as an argument which the mechanist, even according to his own mechanist principles, must accept as scoring some point against his favourite machine; and then I hope that the mechanist, as a man, will see that he can do better and that this sort of argument will always apply against any form of mechanism he espouses. (shrink)

There was once a leak from Hebdomadal Council. The Assessor told her husband, who told my wife, who told me that Monday afternoon had been spent discussing what Lucas would say if various courses of action were adopted, leading to the conclusion that it would be best to do nothing. I was flattered, but a bit surprised. The tide of philosophical scepticism had ebbed, and it was generally allowed that a reasonable way of discovering what someone would say was to (...) ask him. Dick Southwood did: he would quiz me in Common Room – sometimes ending "Thank you for letting me bounce these ideas off you" – and had reliable information about how one member of Congregation would react to various proposals. And not only me: he was a listening Vice-Chancellor, who used to bike from Wellington Square to Merton for lunch, greeting many as he passed them, and ready to stop if occasion warranted it. Of course, there are many other leaks. I remember once attending a meeting in the Town Hall to argue for cycle tracks, and someone coming up to me, and saying, "You’re having a tussle with Council, aren’t you? I think you ought to see the minutes of their latest meeting"; the next day there was a copy in my pigeon hole, giving me just the ammunition I needed. What members of Congregation tend the forget is the existence – the other side of the green baize door, so to speak – of a corps of bedells. (shrink)

This paper responds to Antje du-Bois Pedain’s discussion of the wrongfulness constraint on the criminal law. Du-Bois Pedain argues that the constraint is best interpreted as stating that φing is legitimately criminalised only if φing is wrongful for other-regarding reasons. We take issue with du-Bois Pedain’s arguments. In our view, it is neither a necessary nor sufficient condition of legitimate criminalisation that φing is wrongful in du-Bois Pedain’s sense. Rather, it is a necessary condition of legitimate criminalisation that φing is (...) what we call bare wrongful —that is, that the reasons in favour of φing are defeated by the reasons against. Though du-Bois Pedain is critical of this view, we argue that her criticisms do not convince. (shrink)